Coptis may be used in combination with the R-5081 as an alternative to the Allicin for individuals who experience gastric distress or other problems using the potent garlic bulb extract. Coptis and R-5081 are effective wide-spectrum antimicrobials for combating the Lyme infection.

NOTE: Some users may experience mild to extreme drowsiness when first taking the Coptis. Experience shows that this effect lessens with continued usage.